Intracranial pressure directly predicts headache morbidity in idiopathic intracranial hypertension

Abstract Objective Headache is the predominant disabler in idiopathic intracranial hypertension (IIH). The aim was to characterise headache and investigate association with pressure. Methods IIH:WT a randomised controlled parallel group multicentre trial United Kingdom investigating weight management methods IIH. Participants active IIH (evidenced by papilloedema) body mass index (BMI) ≥35 kg/m 2 were recruited. At baseline, 12 months 24 characteristics quality of life outcome measures collected lumbar puncture measurements performed. Results Sixty-six women included mean age 32.0 years (SD ± 7.8), 43.9 7.0 . phenotype migraine-like 90%. severity correlated ICP at baseline ( r = 0.285; p 0.024); change monthly days 0.454, 0.001 0.419, 0.002 respectively). Cutaneous allodynia significantly months. 0.479, < 0.001). Boot strap analysis noted positive between enabled prediction both days. associated significant improvements (SF-36). Conclusions We demonstrate relationship cutaneous allodynia, which has not been previously reported Those greatest reduction over had frequency severity; this improvement measures. Trial registration This work provides Class IIa evidence raised pressure headache. ClinicalTrials.gov number, NCT02124486